Small angle X-ray measurements on concentrated solutions of Cobalt-bis-porphyrins showed, at all the investigated concentration values, the presence of small aggregates which possess a sphere-like shape with a homogeneous electron density distribution. Such an aggregation, however, is proven not to affect the binding properties of the molecules with amino acids. Indeed, the Cobalt ion of the bis-porphyrins are available for coordinating the nitrogen atom of the amino acid to form a stable complex, as indicated by UV–vis and circular dichroism spectroscopy. The ability of these uncharged water-soluble bis-porphyrins to act as molecular sensors of amino acids in a wide concentration range takes great relevance in biosen-sing applications for which high concentration might be required.

Amino acids recognition by water-soluble uncharged porphyrin tweezers: Spectroscopic evidences in high optical density solutions

MINEO, PLACIDO;
2012

Abstract

Small angle X-ray measurements on concentrated solutions of Cobalt-bis-porphyrins showed, at all the investigated concentration values, the presence of small aggregates which possess a sphere-like shape with a homogeneous electron density distribution. Such an aggregation, however, is proven not to affect the binding properties of the molecules with amino acids. Indeed, the Cobalt ion of the bis-porphyrins are available for coordinating the nitrogen atom of the amino acid to form a stable complex, as indicated by UV–vis and circular dichroism spectroscopy. The ability of these uncharged water-soluble bis-porphyrins to act as molecular sensors of amino acids in a wide concentration range takes great relevance in biosen-sing applications for which high concentration might be required.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/10487
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