A series of 1-aroyl-4H(R)-thiosemicarbazides (IV-XVIII) and the corresponding 5-phenyl-4H(R)-1,2,4-triazolin-3-thiones (XIX-XXXIII) were synthesized: biological assay demonstrated their in vitro antibacterial and antimycotic activities. The preparation of same hydrazinoaroylthiazoles (XXXIV-XXXVI) was reported also, obtained by condensation of 1-aroyl-4H-thiosemicarbazides with phenacyl bromide and the synthesis of thiazole[3,2-b]-s-triazol-3(2H)-ones (XLIX-LI) prepared by cyclodehydration of carboxymethylthiotriazoles (XLVI-XLVIII). The results of pharmacological testing for both series of derivatives (XLIX-LI) and (XLVI-XLVIII) showed good antiinflammatory and antipyretic activities.
|Titolo:||Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, the corresponding 5-aryl 4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmaceutical interest|
|Autori interni:||BONINA, Francesco Paolo|
|Data di pubblicazione:||1981|
|Rivista:||IL FARMACO. EDIZIONE SCIENTIFICA|
|Appare nelle tipologie:||1.1 Articolo in rivista|