Isoxazolidine nucleosides bearing an hydroxyl group at C-3, have been prepared in only three steps, with overall high yields. The synthetic approach is based on the 1,3-dipolar cycloaddition of 3-carboxyalkyl- or acylnitrones to vinyl acetate, followed by condensation with silylated thymine or 5-fluorouracil and NaBH4 reduction. (C) 1996 Elsevier Science Ltd

Isoxazolidine nucleosides bearing an hydroxyl group at C-3, have been prepared in only three steps, with overall high yields. The synthetic approach is based on the 1,3-dipolar cycloaddition of 3-carboxyalkyl- or acylnitrones to vinyl acetate, followed by condensation with silylated thymine or 5-fluorouracil and NaBH4 reduction. (C) 1996 Elsevier Science Ltd

Modified dideoxynucleosides: Synthesis of 2'-N-alkyl-3'-hydroxyalkyl-1',2'-isoxazolidinyl thymidine and 5-fluorouridine derivatives

CHIACCHIO, Ugo;RESCIFINA, Antonio;
1996-01-01

Abstract

Isoxazolidine nucleosides bearing an hydroxyl group at C-3, have been prepared in only three steps, with overall high yields. The synthetic approach is based on the 1,3-dipolar cycloaddition of 3-carboxyalkyl- or acylnitrones to vinyl acetate, followed by condensation with silylated thymine or 5-fluorouracil and NaBH4 reduction. (C) 1996 Elsevier Science Ltd
1996
Isoxazolidine nucleosides bearing an hydroxyl group at C-3, have been prepared in only three steps, with overall high yields. The synthetic approach is based on the 1,3-dipolar cycloaddition of 3-carboxyalkyl- or acylnitrones to vinyl acetate, followed by condensation with silylated thymine or 5-fluorouracil and NaBH4 reduction. (C) 1996 Elsevier Science Ltd
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/10620
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