Treatment of 4-isoxazoline derivatives with methyl iodide affords alpha-beta-enones in excellent yields. The novel rearrangement pathway, proceeding through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.
NOVEL-APPROACH TO THE RING-OPENING OF 4-ISOXAZOLINES - ONE-POT SYNTHESIS OF ALPHA,BETA-ENONES
CHIACCHIO, Ugo;RESCIFINA, Antonio;
1992-01-01
Abstract
Treatment of 4-isoxazoline derivatives with methyl iodide affords alpha-beta-enones in excellent yields. The novel rearrangement pathway, proceeding through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.File in questo prodotto:
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