Truncated phosphonated C-1'-branched N,O-nucleosides have been synthesized in good yields by 1,3-dipolar cycloaddition methodology, starting from N-methyl-C-(diethoxyphosphoryl)nitrone 7. Preliminary biological assays show that beta-anomers are able to inhibit HIV in vitro infection at concentrations in the micromolar range. Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.
|Titolo:||Truncated phosphonated C-1 '-branched N,O-nucleosides: A new class of antiviral agents|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||1.1 Articolo in rivista|