The general antibacterial properties of trospectomycin (TRO) were compared with those of spectomycin (SPEC) in an in vitro study using a collaction of recent clinical isolates: 50 Gram-positive and 25 Gram- negative aerobes and 30 Gram-positive and 15 Gram-nenative anaerobes. Minimum inhinitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for all strains by microtitre using serial dilutions in Mueller-Hinton broth for aerobes and Brucella broth for anaerobes. The final inoculum in each well was 10 5 CFU/ml. This study shows that none of the Gram-negative organisms was sensitive to TRO; the most sensitive were streptococci serobic strains; TRO exibited bacteriicidal activity. The MICs of Staphylococcus epidermidis and Bacteriodes ragilis tested wiht TRO and SPEC were not significantly affected by the size of bacterial inoculum tested, and the nature of the growth medium did not alter the susceptibility tests.

IN VITRO ACTIVITY AGAINST AEROBES AND ANAEROBES OF TROSPECTOMYCIN VERSUS SPECTINOMYCIN

CHISARI, Giuseppe;
1991

Abstract

The general antibacterial properties of trospectomycin (TRO) were compared with those of spectomycin (SPEC) in an in vitro study using a collaction of recent clinical isolates: 50 Gram-positive and 25 Gram- negative aerobes and 30 Gram-positive and 15 Gram-nenative anaerobes. Minimum inhinitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for all strains by microtitre using serial dilutions in Mueller-Hinton broth for aerobes and Brucella broth for anaerobes. The final inoculum in each well was 10 5 CFU/ml. This study shows that none of the Gram-negative organisms was sensitive to TRO; the most sensitive were streptococci serobic strains; TRO exibited bacteriicidal activity. The MICs of Staphylococcus epidermidis and Bacteriodes ragilis tested wiht TRO and SPEC were not significantly affected by the size of bacterial inoculum tested, and the nature of the growth medium did not alter the susceptibility tests.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/10955
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