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EnglishEGF family growth factors consists of growth factors, such as transforming growth factor (TGF)-a, heparinbindingEGF-like growth factor (HB-EGF), amphiregulin (AR) and epiregulin, autocrine growth factors in normal human keratinocytes.HB-EGF is mitogen for epithelial cells and like other members of the EGF family, HB-EGF exerts its biological effects via interactionwith the EGF receptor (EGFR). HB-EGF is an autocrine growth factor for human keratinocytes, and has a possible role as a paracrinegrowth factor for fibroblast. Our report concerning immunohistochemical localization of HB-EGF in normal skin by using the streptavidinperoxidase(HRP) conjugate method, confirms previous data, revealing specific patterns of HB-EGF localization. Identification of HBEGFin cells of epithelial origin suggests its autocrine and/or paracrine roles in epithelial cell maintenance. Our report especially wantsto give a technical contribution, easy to manage and with evident results. A simple technique that does not require use of sophisticatedequipment.
| Titolo: | Immunolocalization of HB-EGF in Human Skin by Streptavidin-Peroxidase (HRP) Conjugate Method |
| Autori interni: | CASTROGIOVANNI, Paola (Primo) IMBESI, Rosa (Ultimo) |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11769/11548 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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