Non-melanoma skin cancers are a common reality worldwide. The principal cause that determines the occurrence of these diseases is theexposition of the sun, which principally causes an alteration in the immune system. Therefore, it is possible that other forms of innate oracquired alterations of the immune system could favor the occurrence of non-melanoma skin cancers.For example, several studies have demonstrated that immunosenescence creates an immunosuppressive state that encourages the developmentof malignances, and new discoveries have noted the importance of T cells and in particular of T regulatory cells (Treg) and T receptorCD28 in this mechanism. Similar results are obtained analyzing the effect of immunosuppressive drugs. The importance of the immune systemand its alteration in the genesis of non-melanoma skin cancers is fundamental for the creation of a new therapeutic and less invasive approach.

Non-melanoma skin cancers in elderly patients

PERROTTA, ROSARIO EMANUELE;MALAGUARNERA, Mariano
2011

Abstract

Non-melanoma skin cancers are a common reality worldwide. The principal cause that determines the occurrence of these diseases is theexposition of the sun, which principally causes an alteration in the immune system. Therefore, it is possible that other forms of innate oracquired alterations of the immune system could favor the occurrence of non-melanoma skin cancers.For example, several studies have demonstrated that immunosenescence creates an immunosuppressive state that encourages the developmentof malignances, and new discoveries have noted the importance of T cells and in particular of T regulatory cells (Treg) and T receptorCD28 in this mechanism. Similar results are obtained analyzing the effect of immunosuppressive drugs. The importance of the immune systemand its alteration in the genesis of non-melanoma skin cancers is fundamental for the creation of a new therapeutic and less invasive approach.
Immunosenescence; Skin cancer; squamocellular carcinoma; T regulatory cells; immunosoppression
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/11844
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