Differential scanning calorimetry has been used to investigate the thermotropic behavior of DPPC liposomes in the presence of different amounts of retinoids in a study of the sites concerned in the mutual lipid-retinoid interaction. The perturbing effect of retinal and retinol on DPPC liposome gel-liquid crystal phase transition has been related to the difference in the polar end group of retinoid. The hydrophilic polar group prevalence over the apolar tail has been evidentiated. Membrane fluidity increases by increasing the retinoid amount. These liposomes displayed a phase separation at high retinal or retinol concentrations

THERMOTROPIC BEHAVIOR OF DIPALMITOYLPHOSPHATIDYLCHOLINE LIPOSOMES CONTAINING RETINOIDS

CASTELLI, Francesco
1987

Abstract

Differential scanning calorimetry has been used to investigate the thermotropic behavior of DPPC liposomes in the presence of different amounts of retinoids in a study of the sites concerned in the mutual lipid-retinoid interaction. The perturbing effect of retinal and retinol on DPPC liposome gel-liquid crystal phase transition has been related to the difference in the polar end group of retinoid. The hydrophilic polar group prevalence over the apolar tail has been evidentiated. Membrane fluidity increases by increasing the retinoid amount. These liposomes displayed a phase separation at high retinal or retinol concentrations
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/11880
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact