The effects of β-cyclodextrin (β-CD) complexation on the absorption and emission properties of the non-steroidal anti-inflammatory drugs tolmetin (TM), diflunisal (DF), and fenbufen (FB) have been investigated. The absorption spectra of all these compds. are only slightly affected by the addn. of β-CD. In contrast, the emission properties were markedly influenced by CD complexation and in a different manner for the three compds. due to a differentiated sensitivity of the excited drugs to the microenvironment. The complexes are all characterized by a 1:1 stoichiometry and two different inclusion geometries for TM-β-CD complexes have been obsd. Induced CD (icd) is obsd. due to the interaction of the compds. with the CD chiral cavity. The icd spectra are characterized by maxima well corresponding to those of the absorption spectra. A nonlinear anal. of the dependence of the icd signal magnitude on the CD concn. provided assocn. consts. values Kass = 1400 ± 100 M-1, 1500 ± 100 M-1, and 2600 ± 150 M-1 for TM, DF, and FB resp.
|Titolo:||On the absorption and emission properties of three new non-steroidal anti-inflammatory drugs-β-cyclodextrin host-guest inclusion complexes: differentiated sensitivity to the microenvironment upon light excitation|
|Data di pubblicazione:||1999|
|Appare nelle tipologie:||1.1 Articolo in rivista|