We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.
Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis
FURNERI, Pio Maria;RAPPAZZO, Giancarlo;
2001-01-01
Abstract
We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Antimicrob. Agents Chemother.-2001-Furneri-2958-60.pdf
accesso aperto
Tipologia:
Versione Editoriale (PDF)
Licenza:
PUBBLICO - Pubblico con Copyright
Dimensione
179.62 kB
Formato
Adobe PDF
|
179.62 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
