A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu+ was synthesised. Copper recognition properties in solution were evaluated using 1H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the newsensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.
A ratiometric naphthalimide sensor for live cell imaging of copper(I)
SATRIANO, Cristina;TRUSSO SFRAZZETTO, GIUSEPPE;AMATO, Maria Emanuela;BALLISTRERI, Francesco Paolo;COPANI, Agata Graziella;GRASSO, GIUSEPPE;PAPPALARDO, ANDREA;TOMASELLI, Gaetano;TOSCANO, Rosa Maria
2013-01-01
Abstract
A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu+ was synthesised. Copper recognition properties in solution were evaluated using 1H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the newsensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.File in questo prodotto:
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