We describe a case of isolated primary laryngeal leishmaniasis in animmunocompetent Italian patient with a previous medical history negative forvisceral or cutaneous leishmaniasis, presenting with hoarseness. We alsosummarize the epidemiological, clinical, and diagnostic features and thetherapeutic management of other cases of laryngeal leishmaniasis inimmunocompetent subjects, described in the literature. Considering the insidious and nonspecific clinical presentation, the increasing number of different formsof mild or underestimated immunosuppressive conditions, and the number of people travelling in endemic zones, along with the ability of Leishmania amastigotes to survive for a long period in the body, we believe it is important forpathologists and clinicians to be aware of this unusual form of leishmaniasis in order to avoid delayed recognition and treatment. The rarity of the presentation and the lack of guidelines on mucosal leishmaniasis may contribute to thepotential undiagnosed cases or delayed diagnosis, the possible relapses, as well as the correct pharmacological and/or surgical therapeutic approach.
We describe a case of isolated primary laryngeal leishmaniasis in an immunocompetent Italian patient with a previous medicalhistory negative for visceral or cutaneous leishmaniasis, presenting with hoarseness. We also summarize the epidemiological,clinical, and diagnostic features and the therapeutic management of other cases of laryngeal leishmaniasis in immunocompetentsubjects, described in the literature. Considering the insidious and nonspecific clinical presentation, the increasing number ofdifferent forms of mild or underestimated immunosuppressive conditions, and the number of people travelling in endemic zones,along with the ability of Leishmania amastigotes to survive for a long period in the body, we believe it is important for pathologistsand clinicians to be aware of this unusual form of leishmaniasis in order to avoid delayed recognition and treatment. The rarity ofthe presentation and the lack of guidelines on mucosal leishmaniasis may contribute to the potential undiagnosed cases or delayeddiagnosis, the possible relapses, as well as the correct pharmacological and/or surgical therapeutic approach.
Isolated laryngeal leishmaniasis in immunocompetent patients: an underdiagnosed disease
COCUZZA, SALVATORE GIUSEPPE;SERRA, Agostino;CALTABIANO, ROSARIO;LANZAFAME, Salvatore;CACOPARDO, Bruno Santi;Nunnari G.
2013-01-01
Abstract
We describe a case of isolated primary laryngeal leishmaniasis in animmunocompetent Italian patient with a previous medical history negative forvisceral or cutaneous leishmaniasis, presenting with hoarseness. We alsosummarize the epidemiological, clinical, and diagnostic features and thetherapeutic management of other cases of laryngeal leishmaniasis inimmunocompetent subjects, described in the literature. Considering the insidious and nonspecific clinical presentation, the increasing number of different formsof mild or underestimated immunosuppressive conditions, and the number of people travelling in endemic zones, along with the ability of Leishmania amastigotes to survive for a long period in the body, we believe it is important forpathologists and clinicians to be aware of this unusual form of leishmaniasis in order to avoid delayed recognition and treatment. The rarity of the presentation and the lack of guidelines on mucosal leishmaniasis may contribute to thepotential undiagnosed cases or delayed diagnosis, the possible relapses, as well as the correct pharmacological and/or surgical therapeutic approach.File | Dimensione | Formato | |
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