Male breast cancer is a rare neoplasm. Adhesions in its deeper and superficial levels and axillary adenopathies (50-60%) are often found at the diagnosis time. Surgery is considered the main step in the treatment of the male breast cancer. Radical mastectomy often leads to a wide asportation of the skin consequently causing some problems in the management of the chest-wall defect. Otherwise inadequate resections can cause local recurrences. The Authors, after a brief analysis of the main aspects concerning the prognosis and the management of the male breast cancer, report the use of transverse thoracoepigastric skin flap in the reconstruction of surgical wound after mastectomy.