A literature review of the treatment of cartilage defects was conducted, examining the current literature on the well-known treatments. In particular, advantages and drawbacks of each of the discussed treatments were evaluated with outcomes available in literature. The literature search was conducted on PubMed and Scopus using appropriate keywords in relation to cartilage defects. Main research articles were selected for review.Cartilage damage affects thousands of persons each year; they are treated with implants and surgery. A great problem in treatments of cartilage defects is the inability of cartilage to repair, which reduces the effectiveness of the treatment. In addition, cyclic loading of joints further degrades cartilage even after treatment. In relation to the conditions of the cartilage lesions and features of the patients, a specific treatment is more appropriate than others. Current treatments are often unpredictable in results but could results in long term improvements for many patients, especially young patients.The well-known treatments such as osteochondral implants, bone marrow stimulation techniques, chondrogenic cell implantations have advantages and drawbacks that have led to seek new strategies such as scaffold materials. In this review we describe benefits and disadvantages of the well-known methods of cartilage regeneration that seem to have a better long-term effectiveness.

Current concepts in the treatment of cartilage damage. A review

MUSUMECI, GIUSEPPE
Primo
;
LORETO, CARLA AGATA;CASTORINA, Sergio;IMBESI, Rosa;Leonardi R;CASTROGIOVANNI, Paola
Ultimo
2013

Abstract

A literature review of the treatment of cartilage defects was conducted, examining the current literature on the well-known treatments. In particular, advantages and drawbacks of each of the discussed treatments were evaluated with outcomes available in literature. The literature search was conducted on PubMed and Scopus using appropriate keywords in relation to cartilage defects. Main research articles were selected for review.Cartilage damage affects thousands of persons each year; they are treated with implants and surgery. A great problem in treatments of cartilage defects is the inability of cartilage to repair, which reduces the effectiveness of the treatment. In addition, cyclic loading of joints further degrades cartilage even after treatment. In relation to the conditions of the cartilage lesions and features of the patients, a specific treatment is more appropriate than others. Current treatments are often unpredictable in results but could results in long term improvements for many patients, especially young patients.The well-known treatments such as osteochondral implants, bone marrow stimulation techniques, chondrogenic cell implantations have advantages and drawbacks that have led to seek new strategies such as scaffold materials. In this review we describe benefits and disadvantages of the well-known methods of cartilage regeneration that seem to have a better long-term effectiveness.
cartilage; cartilage degeneration; cartilage repair
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/14449
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