We report the clinical, sonographic and pathologic features of a rare case of primary fibromatosis of the breast parenchyma in a 29-year-old female. Unlike most cases reported in the literature, this tumor presented as an oval-shaped nodular mass lacking the typical infiltrating (finger-like) margins both at ultrasonography and macroscopic examination. Frozen section diagnosis revealed a spindle cell proliferation entrapping mammary ducts and lobules and, thus, the provisional diagnosis of “fibromatosis-like spindle cell proliferation” was rendered, but the possibility of a spindle cell metaplastic carcinoma could not be completely ruled out. The final diagnosis was achieved in formalin-fixed tissues by a combined morphological and immunohistochemical study. Tumor was composed of long, interlacing fascicles of bland-looking spindle-shaped cells embedded in a variably fibrous stroma. Only focally tumor margins were of infiltrative type. Immunohistochemically neoplastic cells were stained diffusely with vimentin, -smooth muscle actin and -catenin. Awareness that fibromatosis of the breast may exhibit an unusual benign-like nodular appearance is crucial to avoid an underrecognition of this locally aggressive tumor.

Fibromatosis of the breast parenchyma with a benign-like nodular appearance

Salvatorelli L
Primo
;
MUSUMECI, GIUSEPPE
Secondo
;
PARENTI, Rosalba;MAGRO, Gaetano Giuseppe
Ultimo
2013

Abstract

We report the clinical, sonographic and pathologic features of a rare case of primary fibromatosis of the breast parenchyma in a 29-year-old female. Unlike most cases reported in the literature, this tumor presented as an oval-shaped nodular mass lacking the typical infiltrating (finger-like) margins both at ultrasonography and macroscopic examination. Frozen section diagnosis revealed a spindle cell proliferation entrapping mammary ducts and lobules and, thus, the provisional diagnosis of “fibromatosis-like spindle cell proliferation” was rendered, but the possibility of a spindle cell metaplastic carcinoma could not be completely ruled out. The final diagnosis was achieved in formalin-fixed tissues by a combined morphological and immunohistochemical study. Tumor was composed of long, interlacing fascicles of bland-looking spindle-shaped cells embedded in a variably fibrous stroma. Only focally tumor margins were of infiltrative type. Immunohistochemically neoplastic cells were stained diffusely with vimentin, -smooth muscle actin and -catenin. Awareness that fibromatosis of the breast may exhibit an unusual benign-like nodular appearance is crucial to avoid an underrecognition of this locally aggressive tumor.
fibromatosis; frozen section diagnosis; breast
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/14554
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact