Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection.

In humans, Ad36 increases adiposity and attenuates deterioration of glycemic control, and we observed a possible beneficial metabolic effect of Ad36 seropositivity, seemingly facilitating weight and fatty liver loss by dietary intervention in obesity. This is a further challenge to the concept of systematic unfavorable effects of all virus infections on the liver and other body organs. Human microbiome cannot be considered just the gut bacterial milieu, but it is the totality of microbes and their genetic elements and environmental interactions within an individual in all the organs and systems. Recent reports empower and support the concept that a more comprehensive model of microbiome should be considered, including viruses and past virus infection effects. This field of clinical research deserves a greater integration of knowledge regarding the link of metabolic and nutritional disease and the relationship of adipocytes and hepatocytes with the microbiome.