Protein S deficiency and APC-resistance associated with recurrent thrombosis

We observed a young man who had been by a vena cava thrombosis and hereditary S deficiency with APC-resistence. However, non strenuous, protracted and repeated physical trauma may have acted synergically with the congenital coagulation inhibitor deficiency, determining the thrombotic episodes, which are probably provoked by transient and functional alterations of the non thrombogenic properties of the endothelium.