The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clinical situations which previously were regarded as contraindications. Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool. When allocated to serology-matched recipients, kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list. Special care must be dedicated to the pre-transplant evaluation of potential candidates, particularly with regard to liver functionality and evidence of liver histological damage, such as cirrhosis, that could be a contraindication to transplantation. Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results, which may be affected by the progression of liver disease in the recipients. An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome.
Kidney transplantation, Deceased donor, Hepatitis C virus, De novo glomerulonephritis, Liver failure, Graft survival, End-stage renal disease, Hemodialysis
|Titolo:||Kidney transplantation from donors with hepatitis C infection.|
|Autori interni:||VEROUX, Massimiliano|
|Data di pubblicazione:||2014|
|Rivista:||WORLD JOURNAL OF GASTROENTEROLOGY |
WORLD JOURNAL OF GASTROENTEROLOGY
|Appare nelle tipologie:||1.1 Articolo in rivista|