We evaluated in elderly subjects (a) the ability of GFR formulas to discriminate chronic kidney disease (CKD), (b) the correlation between renal morphology and function, and (c) the usefulness of combined r-US and GFR formulas to detect CKD. A total of 72 patients were enrolled (mean age 80 ± 7 years,male sex 44%, serumcreatinine 0.98 ± 0.42mg/dL, and CKD 57%). Cockcroft-Gault showed the highest sensitivity (78%) and specificity (94%) for CKD and was correlated with kidney volume ( = 0.68, < 0.001). All formulas failed to provide a reliable estimate of GFR. In multivariate analysis, Cockcroft-Gault < 52 mL/min and kidney sinus section area < 28 cm2 showed the highest accuracy for the identification of CKD subjects (AUC 0.90, < 0.001). MDRD and CKD-EPI differed significantly for GFR ≥90 mL/min. Conclusions. Cockcroft-Gault < 52 mL/min was able to discriminate subjects with CKD but all formulas failed to provide a reliable estimate of GFR. The combined use of r-US and Cockcroft-Gault formula improved the ability to discriminate CKD in elderly subjects.
|Titolo:||Renal function and ultrasound imaging in elderly subjects.|
|Autori interni:||CASTELLINO, Pietro|
FATUZZO, Pasquale Mario
|Data di pubblicazione:||2014|
|Rivista:||THE SCIENTIFIC WORLD JOURNAL|
|Appare nelle tipologie:||1.1 Articolo in rivista|