Cutaneous Rosai-Dorfmann Disease in Autistic Patient: Is there a Pathogenetic Correlation?

Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a benign disorder of histiocyte proliferation that usually affects the lymph nodes. Purely Cutaneous Rosai-Dorfman Disease (CRDD) is a rare extranodal variant that is strictly limited to the skin. We report a patient with of cutaneous rosai-dorfman of the abdominal wall with a past medical history of autism spectrum disorders. Autism is surely a complex disease and the most prevailing opinion is that it is a neuro-immune disorder. Both the diseases are considered strictly correlated to the immune disorders and the immunodeficiency might play an important pathogenetic role. A brief review of the literature of CRDD is also provided.