The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations. Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds. Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV. No specific antiviral activity was observed in the cases at hand. Novel compounds were prepared for future biological tests.
|Titolo:||Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: A standard protocol|
|Data di pubblicazione:||2014|
|Citazione:||Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: A standard protocol / Quadrelli, Paolo; Vazquez Martinez, Naira; Scrocchi, Roberto; Corsaro, Antonino; Pistarà, Venerando. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 2356-6140. - 2014:492178(2014).|
|Appare nelle tipologie:||1.1 Articolo in rivista|