A multivariate insight into Ionic Liquids' (ILs) toxicity, a broad term highly dependent on the biologicalsystems adopted as “sensors”, addressed four main groups of toxicities: aquatic toxicity, toxicity towardsfungi and bacteria, cytotoxicity towards IPC-81 rat cell lines and acetylcholinesterase enzyme inhibition.This approach, summarizing toxicity information available from a huge amount of scattered literaturedata, allowed derivation of aquatic toxicity scores for 104 ILs and bacteria and fungi toxicity scores for 87ILs as well as identification of a correlation between aquatic ecotoxicity and the response of IPC-81 ratcell lines. Further evidence on the effects of cation structural features such as the increase of IL toxicityon increasing the length of the side chain and its decrease when oxygen atoms are present in the sidechain was obtained. Maximum dialkyloxyether imidazolium toxicity was observed for ILs having 7–9carbon atoms in each side chain, while toxicity decreased for ILs with a higher number of carbons,probably due to the formation of micellar aggregates.

A multivariate insight into ionic liquids toxicities

MUSUMARRA, Giuseppe;SCIRE', Salvatore
2014-01-01

Abstract

A multivariate insight into Ionic Liquids' (ILs) toxicity, a broad term highly dependent on the biologicalsystems adopted as “sensors”, addressed four main groups of toxicities: aquatic toxicity, toxicity towardsfungi and bacteria, cytotoxicity towards IPC-81 rat cell lines and acetylcholinesterase enzyme inhibition.This approach, summarizing toxicity information available from a huge amount of scattered literaturedata, allowed derivation of aquatic toxicity scores for 104 ILs and bacteria and fungi toxicity scores for 87ILs as well as identification of a correlation between aquatic ecotoxicity and the response of IPC-81 ratcell lines. Further evidence on the effects of cation structural features such as the increase of IL toxicityon increasing the length of the side chain and its decrease when oxygen atoms are present in the sidechain was obtained. Maximum dialkyloxyether imidazolium toxicity was observed for ILs having 7–9carbon atoms in each side chain, while toxicity decreased for ILs with a higher number of carbons,probably due to the formation of micellar aggregates.
2014
Liquidi ionici; Ionic liquids; Toxicity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/16665
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