This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG2000 and three different α-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10-5 M, that are interesting in the view of an vivo administration. The PEG-LAA micelles also showed a good stability at 37°C and upon dilution in aqueous media. Using a colored probe as a model lipophilic compound, the loading efficiency and in vitro release profile were also outlined.
|Titolo:||Characterization of micellar systems produced by new amphiphilic conjugates of poly(ethylene glycol)|
|Autori interni:||PIGNATELLO, Rosario|
LA ROSA, Carmelo
|Data di pubblicazione:||2014|
|Rivista:||DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY|
|Appare nelle tipologie:||1.1 Articolo in rivista|