Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials

Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal-chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal-chelating beta-cyclodextrin polymer bear-ing 8-hydroxyquinoline ligands. The metal ions (Cu2+ or Zn2+) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self-and metal-induced A beta aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble beta-cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.