The ferrocenyl analogue of clotrimazole, in which the metallocene fragment replaces one of the phenyl rings in the triphenylmethane system, and a related isomer were prepared through the direct substitution of a methoxygroup in the α-position to ferrocene with imidazole in the key step. The obtained ferrocenyl derivatives were spectroscopically characterized and in a preliminary assay for bioactivity their cell growth inhibitory activity on two different human cancer cell lines was evaluated. In comparison with the parent drug the ferrocene analogues displayed about two-fold increase of cytotoxicity on HT29 colorectal cancer cells, whereas comparable activity was displayed against MCF-7 breast cancer cell line.
|Titolo:||Synthesis of the ferrocenyl analogue of clotrimazole drug.|
|Data di pubblicazione:||2017|
|Citazione:||Synthesis of the ferrocenyl analogue of clotrimazole drug. / Sonia Pedotti; Martina Ussia; Angela Patti; Nicolò Musso; Vincenza Barresi; Condorelli D. - In: JOURNAL OF ORGANOMETALLIC CHEMISTRY. - ISSN 0022-328X. - 830:-(2017), pp. 56-61.|
|Appare nelle tipologie:||1.1 Articolo in rivista|