Cerebral gliosarcoma. On the possible pericytial origin of the sarcomatous component

We have reported two cases of cerebral gliosarcoma by immunohistochemical method. The antibodies anti S-100, anti GFAP and anti vimentin have supported the presence of glial and mesenchymal elements. Factor VIII has labeled the endothelium of the newly formed vessels. Collagen IV has shown atypical cells in the thickness of the vascular walls, and ribbons of adventitial cells throwing in the surrounding parenchyma. By these results, the pericitic origin of the sarcomatous elements could be hypothesized