Diesel fumes and the rising prevalence of atopy: an urban legend?

Recently, the incidence of allergic diseases has increased in most industrialized conntries of the World. Persistent exposure to particulate, air pollution from motor vehicles has been implicated as one of the factors that is resonsible for the observed increased prevalence of atopy. Epidemiologic studies conducted in different parts of the,world have demonstrated an important association between ambient levels of motor vehicle traffic emissions and increased symptoms' of asthma and rhinitis. Additionally, recent human and animal laboratory-based studies have shown that particulate toxic pollutants, and in particular diesel exhaust particles (IDEP), can enhance allergic inflammation and induce the development of allergic immune responses. In this article, our current understanding of the mechanisms by which pollutants such as DEPs enhance the underlying allergic inflammatory response is reviewed, and the evidence that supports the causative link between particulate air pollution from motor vehicles and increasing allergic diseases is discussed.