New conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems

Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transition metal complexes, especially manganese(III) complexes with porphyrin and salen-type ligands, have been reported to be superoxide scavengers. Here we report the synthesis and spectroscopic characterization of manganese(III) complexes of 5[4-(6-O-b-cyclodextrin)-phenyl],10,15,20-tri(4-hydroxyphenyl)-porphyrin and of 6A-deoxy-6A[(S-cysteamidobenzoyl(3,4-diamino)-N,N¢-bis(salicylidene))]-b-cyclodextrin. The superoxide dismutase activity of the metal complexes was investigated by indirect methods. The catalase and peroxidase activities were tested using ABTS assays.