3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-L-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be considered for novel combination therapy against HCV infection using nucleoside inhibitors and non-nucleoside inhibitors of HCV NS5B.
|Titolo:||Stereoselective Synthesis and Biological Evaluations of Novel 3′-Deoxy-4′-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication|
|Data di pubblicazione:||2009|
|Citazione:||Stereoselective Synthesis and Biological Evaluations of Novel 3′-Deoxy-4′-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication / CHIACCHIO U; BORRELLO L; CRISPINO L; RESCIFINA A; MERINO P; MACCHI B; BALESTRIERI E; MASTINO A; PIPERNO A; ROMEO G. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 52:13(2009), pp. 4054-4057.|
|Appare nelle tipologie:||1.1 Articolo in rivista|