Malattia di Parkison e superficie oculare [Parkinson's disease and ocular surface]

Purpose: The Authors want to evaluate the effect of anew generation tear substitute (carboxymethylcellulose CMC0.5%, erithrol, L-carnitine, glycerine, purite®) on the ocularecosystem applied in patients with Parkinson’ disease and dryeye syndrome.Methods: 50 patients (21 F- 29 M mean age 68+/- 5 yr)with signs of discomfort and/or ocular dryness (burning, feelingof extraneous body, dryness and itch) were admitted to ourstudy. Patients were treated with carboxymethylcellulose CMC,for 28 days. Subjective symptoms and the objective signs wereconsidered at the first visit, 28 days after therapy and 5 daysafter wash out following the 28 days of therapy. Studied parameterswere: Schirmer I (mm/5 min); Schirmer II (mm/3 min);time of breakup of the film of shed tears (BUT, sec) andconjunctival buffer for the search of aerobic and anaerobicbacteria.Results: The data show a change in the tear test consideredin our study, with the following results : Schirmer I 8.3 -11.8; Schirmer II 7.7 - 10.9 ; BUT 7.3 - 11.3 before and afterthe treatment respectively. The colture examinations show aninitial bacterial increase of 40 strains (43.7%) compared to 23(22.5%) after the treatment.Conclusion: The results show that carboxymethylcellulose0.5% has good regulating activity and its clinical effectivenessis confirmed by a direct activity in normalizing clinicalparameters of shed tears film and an indirect activity in selectingnormal bacterial flora.