We have measured plasma adrenocorticotropin and corticosterone levels after injection of interleukin-1 alpha, in 2- and 24 month-old Sprague-Dawley rats following weekly treatment with the immunomodulator Pidotimod. Blood samples were withdrawn -30, 0, 30, 60, 90, and 120 min after interleukin-l injection. Interleukin-l stimulated ACTH and corticosterone secretion in a dose-related manner with different AUC depending upon treatment in both 2- and 24 month-old Sprague-Dawley rats. Results suggest that immunomodulators may restore the functional integrity of adrenal-immune feedback during aging
Effects of pidotimod on the immune adrenal feedback in the aging rat
BARBERA, NUNZIATA GIUSEPPA ELISABETTA;CANTARELLA, GIUSEPPINA;BERNARDINI, Renato
1994-01-01
Abstract
We have measured plasma adrenocorticotropin and corticosterone levels after injection of interleukin-1 alpha, in 2- and 24 month-old Sprague-Dawley rats following weekly treatment with the immunomodulator Pidotimod. Blood samples were withdrawn -30, 0, 30, 60, 90, and 120 min after interleukin-l injection. Interleukin-l stimulated ACTH and corticosterone secretion in a dose-related manner with different AUC depending upon treatment in both 2- and 24 month-old Sprague-Dawley rats. Results suggest that immunomodulators may restore the functional integrity of adrenal-immune feedback during agingFile in questo prodotto:
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