Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA

Choi, JK; D'URSO, ALESSANDRO; Balaz, M.

doi:10.1016/j.jinorgbio.2013.05.018

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We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl) porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)(2). NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum. (c) 2013 Elsevier Inc. All rights reserved.

Titolo:	Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA
Autori interni:	Choi JK D'URSO, ALESSANDRO Balaz M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2013
Rivista:	JOURNAL OF INORGANIC BIOCHEMISTRY
Abstract:	We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl) porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)(2). NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum. (c) 2013 Elsevier Inc. All rights reserved.
Handle:	http://hdl.handle.net/20.500.11769/253044
Appare nelle tipologie:	1.1 Articolo in rivista

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