The synthesis of carbocyclic 2′-oxa-3′-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.
Synthesis and Biological Evaluation of Phosphonated Carbocyclic 2′-Oxa-3′-aza-nucleosides
CHIACCHIO, Ugo;RESCIFINA, Antonio;
2006-01-01
Abstract
The synthesis of carbocyclic 2′-oxa-3′-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.File in questo prodotto:
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