Medulloblastoma is a rare tumor in central nervous system, with an even rarer occurrence in adulthood. The management ofa recurrent disease is a medical challenge; chemotherapy has been used as the treatment of choice, while reirradiation has beenemployed in selected cases. We report the case of a 51-year-old man with recurrent medulloblastoma. He was treated with localreirradiation, chemotherapy, and antiangiogenic drug, with the latter giving the longer progression-free interval. The aim ofthis report is to show that recurrent medulloblastoma in adults can be approached with a multimodality treatment and thatantiangiogenic therapy should have a role in the management of this disease.