Objectives: To evaluate the role of genetic background in osteoporosis/osteopenia development in beta-Thalassemia Major patients. Design and methods: The influence of VDR (FokI, BsmI) as well as COLIA1 (Sp1) gene polymorphisms on BMD was investigated in 40 patients. Results: Although the examined gene polymorphisms did not significantly affect BMD variations in our population, BsmI was found to display beneficial effects on patient response to alendronate therapy. Conclusion: Genetic factors retain a potential role for improvement of osteoporosis management in thalassemic patients
Role of genetic pattern on bone mineral density in thalassemic patients
GAUDIO, AGOSTINO;
2010-01-01
Abstract
Objectives: To evaluate the role of genetic background in osteoporosis/osteopenia development in beta-Thalassemia Major patients. Design and methods: The influence of VDR (FokI, BsmI) as well as COLIA1 (Sp1) gene polymorphisms on BMD was investigated in 40 patients. Results: Although the examined gene polymorphisms did not significantly affect BMD variations in our population, BsmI was found to display beneficial effects on patient response to alendronate therapy. Conclusion: Genetic factors retain a potential role for improvement of osteoporosis management in thalassemic patientsFile in questo prodotto:
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