Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer. Such an increase of HGF and COX-2 expression was blunted in rats pretreated with adrenomedullin. Pretreatment with adrenomedullin and the adrenomedullin22-52 fragment did not result in changes of HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Pretreatment with adrenomedullin and the calcitonin gene-related peptide8-37 fragment (CGRP8-37) increased HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Our results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors.
Titolo: | Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat | |
Autori interni: | ||
Data di pubblicazione: | 2005 | |
Rivista: | ||
Handle: | http://hdl.handle.net/20.500.11769/27301 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |