Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat

Cantarella, Giuseppina; Martinez, G; Cutuli, Vm; Loreto, Carla Agata; D'Alcamo, M; Prato, A; Amico Roxas, M; Bernardini, Renato; Clementi,

doi:10.1016/j.ejphar.2005.06.001

Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer. Such an increase of HGF and COX-2 expression was blunted in rats pretreated with adrenomedullin. Pretreatment with adrenomedullin and the adrenomedullin22-52 fragment did not result in changes of HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Pretreatment with adrenomedullin and the calcitonin gene-related peptide8-37 fragment (CGRP8-37) increased HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Our results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors.

Titolo:	Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat
Autori interni:	CANTARELLA, GIUSEPPINA MARTINEZ G CUTULI VM LORETO, CARLA AGATA D'ALCAMO M PRATO A AMICO ROXAS M BERNARDINI, Renato CLEMENTI mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2005
Rivista:	EUROPEAN JOURNAL OF PHARMACOLOGY
Handle:	http://hdl.handle.net/20.500.11769/27301
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11769/27301

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