The effect of morphine, naloxone, codeine and ethylmorphine on the thermotropic properties of dipalrnitoylphosphatidylcholine (DPPC) liposomes has been examined by differential scanning calorimetry. Ali the drugs in this series eliminated the DPPC pre-transition peak. Moreover, both codeine and ethylmorphine showed a noticeable shift of the gel-liquid crystal transition peak Tm towards lower values, along with a broadening of the meIting peak and a slight variation in the enthalpy of melting. The different thermotropic behaviour among this series of opioids could be explained by structural features such as the different substitution on the alcohol function of the aromatic ring of the benzomorphane moiety.

OPIOID STRUCTURE - LIPID THERMOTROPIC BEHAVIOR CORRELATION STUDY ON A SERIES OF DPPC LIPOSOMES CONTAINING OPIOIDS

CASTELLI, Francesco;
1989

Abstract

The effect of morphine, naloxone, codeine and ethylmorphine on the thermotropic properties of dipalrnitoylphosphatidylcholine (DPPC) liposomes has been examined by differential scanning calorimetry. Ali the drugs in this series eliminated the DPPC pre-transition peak. Moreover, both codeine and ethylmorphine showed a noticeable shift of the gel-liquid crystal transition peak Tm towards lower values, along with a broadening of the meIting peak and a slight variation in the enthalpy of melting. The different thermotropic behaviour among this series of opioids could be explained by structural features such as the different substitution on the alcohol function of the aromatic ring of the benzomorphane moiety.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/27778
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