Liposomes and monolayers were used as membrane models to examine the interaction of lecithin and the opioid agonist ethylmorphine. By calorimetric measurements, the ability of the drug to increase the fluidity of the lipid has been explained by electrostatic interaction between the drug and the polar headgroup of the lipid. Compression isotherms and penetration kinetics of the lipid monolayers in the presence of the drug confirmed the previous observations
ETHYLMORPHINE-LIPID INTERACTION STUDY BY CALORIMETRY AND MONOLAYER TECHNIQUES
CASTELLI, Francesco;
1988-01-01
Abstract
Liposomes and monolayers were used as membrane models to examine the interaction of lecithin and the opioid agonist ethylmorphine. By calorimetric measurements, the ability of the drug to increase the fluidity of the lipid has been explained by electrostatic interaction between the drug and the polar headgroup of the lipid. Compression isotherms and penetration kinetics of the lipid monolayers in the presence of the drug confirmed the previous observationsFile in questo prodotto:
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