The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or [bis-(heteroarylamino)methyl]arenes (5). The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction. Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.
Formation of (N-heteroaryl)heteroarylmethanamines from heteroaromatic aldehydes and heteroaromatic amines
MUSUMARRA, Giuseppe;
1994-01-01
Abstract
The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or [bis-(heteroarylamino)methyl]arenes (5). The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction. Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.File in questo prodotto:
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