A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

Fraix A;CARDILE, Venera;GRAZIANO, ADRIANA CAROL;SORTINO, Salvatore
2013-01-01

Abstract

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.
File in questo prodotto:
File Dimensione Formato  
2013Chem comm.pdf

non disponibili

Dimensione 2.19 MB
Formato Adobe PDF
2.19 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/27931
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 67
  • ???jsp.display-item.citation.isi??? 63
social impact