A dataset of 50 compounds was used to generate a QSAR model and to design 9 newheteroaryl ethylenes. These compounds were synthesized, tested in vitro and asignificant agreement with in silico predictions observed. Studies using LaserScanning Confocal Microscopy pointed out that the compounds may act by different mechanisms.
Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line
BARRESI, VINCENZA;BONACCORSO, CARMELA;CONSIGLIO, GIUSEPPE;MUSSO, NICOLO';MUSUMARRA, Giuseppe;SATRIANO, Cristina;FORTUNA, COSIMO GIANLUCA
2013-01-01
Abstract
A dataset of 50 compounds was used to generate a QSAR model and to design 9 newheteroaryl ethylenes. These compounds were synthesized, tested in vitro and asignificant agreement with in silico predictions observed. Studies using LaserScanning Confocal Microscopy pointed out that the compounds may act by different mechanisms.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
51 2013 MolBiosyst Barresi.pdf
solo gestori archivio
Dimensione
1.46 MB
Formato
Adobe PDF
|
1.46 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
