The in vitro antitumor activities of 2,6-di-[2-(heteroaryl)vinyl]pyridines versus the standard National Cancer Institute 60 cell lines panel and of 2.6-di-[2-(heteroaryl)vinyl] pyridinium cations versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. Antiproliferative effects in both series are particularly evident for MCF7 mammary adenocarcinoma cells. Multivariate analysis of DNA microarray data for responsive tumor cell lines suggest a mechanistic pathway involving polyamine biosynthesis and prolactin signal transduction. (C) 2002 Elsevier Science Ltd. All rights reserved.
In vitro antitumor activities of 2,6-di-[2-(Heteroaryl)vinyllpyridines and pyridiniums
BARRESI, VINCENZA;CONDORELLI, Daniele Filippo;FORTUNA, COSIMO GIANLUCA;MUSUMARRA, Giuseppe;SCIRE', Salvatore
2002-01-01
Abstract
The in vitro antitumor activities of 2,6-di-[2-(heteroaryl)vinyl]pyridines versus the standard National Cancer Institute 60 cell lines panel and of 2.6-di-[2-(heteroaryl)vinyl] pyridinium cations versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. Antiproliferative effects in both series are particularly evident for MCF7 mammary adenocarcinoma cells. Multivariate analysis of DNA microarray data for responsive tumor cell lines suggest a mechanistic pathway involving polyamine biosynthesis and prolactin signal transduction. (C) 2002 Elsevier Science Ltd. All rights reserved.File in questo prodotto:
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