Effects of long-term oral sildenafil treatment for pulmonary hypertension in infant with bronchopulmonary dysplasia. Physical and psychological implication in a case report

The indication to use sildenafil is still off label in many countries and no results from controlled clinical trials, nor shared guidelines are available. Its clinical maybe advantageous especially in those areas where medical AIDS and medications such as high frequency ventilation, nitric oxide and surfactant are not available for infants with pulmonary hypertension. Case Presentation: A preterm infant with severe pulmonary hypertension, associated with bronchopulmonary dysplasia was treated with oral sildenafil in combination with nitric oxide. Conclusions: Beside an evident clinical improvement, sildenafil has led to a significant reduction of pulmonary hypertension. Thus we proved that a long-term oral sildenafil therapy as part of an aggressive treatment program is well-tolerated without significant adverse events