Sclerosing angiomatoid nodular transformation of the spleen is a rare benign vascular lesion with extensive sclerosis and unknown aetiology. Although its pathogenesis is not clear, it has been postulated that it may represent a peculiar hamartomatous transformation of red pulp in response to an exaggerated non-neoplastic stromal proliferation. However, it is unclear whether SANT is the end stage of a variety of benign splenic conditions including inflammatory pseudotumour, hamartoma or hematoma. Considering that the lesion is benign, splenectomy is curative. We report a new case of SANT, discussing differential diagnosis, immunohistochemical profile and pathogenesis.

A case of sclerosing angiomatoid nodular transformation of the spleen

CALTABIANO, ROSARIO
Secondo
;
LANZAFAME, Salvatore
2013-01-01

Abstract

Sclerosing angiomatoid nodular transformation of the spleen is a rare benign vascular lesion with extensive sclerosis and unknown aetiology. Although its pathogenesis is not clear, it has been postulated that it may represent a peculiar hamartomatous transformation of red pulp in response to an exaggerated non-neoplastic stromal proliferation. However, it is unclear whether SANT is the end stage of a variety of benign splenic conditions including inflammatory pseudotumour, hamartoma or hematoma. Considering that the lesion is benign, splenectomy is curative. We report a new case of SANT, discussing differential diagnosis, immunohistochemical profile and pathogenesis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/28857
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