Natural asbestiform fbers are defned 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fbers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to fnd any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was signifcantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were signifcantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defned inflammosome by FE fbers.

Immunomodulatory effects in workers exposed to naturally occurring asbestos fbers

LEDDA, CATERINA
Primo
;
RAPISARDA, VENERANDO
Penultimo
;
LORETO, CARLA AGATA
Ultimo
2017-01-01

Abstract

Natural asbestiform fbers are defned 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fbers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to fnd any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was signifcantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were signifcantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defned inflammosome by FE fbers.
2017
Biancavilla; Cytokine; Fibers; Fluoro-edenite; Inflammasome; Interleukin; Malignant pleural mesothelioma; NLRP3; Biochemistry; Molecular Medicine; Molecular Biology; Oncology; Genetics; Cancer Research
Biancavilla; Cytokine; Fibers; Fluoro-edenite; Inflammasome; Interleukin; Malignant pleural mesothelioma; NLRP3; Biochemistry; Molecular Medicine; Molecular Biology; Oncology; Genetics; Cancer Research
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/302269
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