Doxorubicin (DXR) (10(-4) mol/l) causes histamine release from isolated rat mast cells. At lower doses (range 10(-8) mol/l-10(-5) mol/l) the drug failed to evoke secretion. In the 10(-5) mol/l-10(-4) mol/l range there is a significant decrease of the ATP intracellular levels. Fructose 1,6-diphosphate (FDP) produced a sharp increase of the ATP content of the DXR treated cells. In particular, FDP pretreatment inhibited the DXR stimulated histamine release.
Titolo: | Mast cell histamine release induced by doxorubicin and the inhibitory effect of fructose 1,6-diphosphate. |
Autori interni: | |
Data di pubblicazione: | 1983 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11769/30537 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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