Successful meticillin-resistant Staphylococcus aureus (MRSA) clones have evolved to adapt to healthcare,community and livestock environments. This review will bring together recent studies into cloneadaptation and the importance of genes acquired during horizontal gene transfer to survival in specificenvironments. It will also discuss the role of global regulators controlling virulence gene expression andresistance to antibiotics, such as the agr and vraRS systems. Understanding these processes in successfulclones could reveal novel targets for therapeutic agents, which are urgently required to reduce theinfection burden and improve treatment options.
Meticillin-resistant Staphylococcus aureus (MRSA) update: New insights into bacterial adaptation and therapeutic targets
STEFANI, Stefania
2014-01-01
Abstract
Successful meticillin-resistant Staphylococcus aureus (MRSA) clones have evolved to adapt to healthcare,community and livestock environments. This review will bring together recent studies into cloneadaptation and the importance of genes acquired during horizontal gene transfer to survival in specificenvironments. It will also discuss the role of global regulators controlling virulence gene expression andresistance to antibiotics, such as the agr and vraRS systems. Understanding these processes in successfulclones could reveal novel targets for therapeutic agents, which are urgently required to reduce theinfection burden and improve treatment options.| File | Dimensione | Formato | |
|---|---|---|---|
|
MRSA ADAPATION - JGAR 2014.pdf
solo gestori archivio
Licenza:
Non specificato
Dimensione
434.29 kB
Formato
Adobe PDF
|
434.29 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
