Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mildto- moderate acne. Methods: In this eight-week multicenter study, patients were randomized to either a hydrogen peroxidebased or a benzoyl peroxide-based regimen. The primary outcome measure of clinical response was assessed using the Global acne Grading System (GaGS) at baseline, four weeks, and eight weeks. at Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit. Results: Both treatment regimens were associated with improvement of GaGS score at Week 8 compared to baseline (p<0.0001). GaGS score did not diBer significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly eBective and cosmetically acceptable. Conclusion: a novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide-based regimen in the treatment of mild-to-moderate acne.
|Titolo:||Results of a multicenter, randomized, controlled trial of a hydrogen peroxide-based kit versus a benzoyl peroxide-based kit in mild-to-moderate acne|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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