In recent years a number of studies have reported the significant relationship between metabolic syndrome andneurodegenerative disease. There is accumulating evidence that the interplay of combined genetic andenvironmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes maybe advocated for to explain the pandemic of neurodegenerative diseases. In recent years a specific FermentedPapaya Preparation (FPP) has been shown to significantly affect a number of redox signalling abnormalities in avariety of chronic diseases and as well in aging mechanisms either on experimental and on clinical ground. The aimof the present study was to evaluate FPP use in impending metabolic disease patients with potentiallyneurodegenerative disease clustered risk factors. The study population consisted of 90 patients aged 45-65 yearsold, with impending metabolic syndrome and previously selected as to be ApoE4 genotype negative. By applying aRCT, double-blind method, one group received FPP 4.5 g twice a day (the most common dosage utilized in priorclinical studies) while the other received an oral antioxidant cocktail (trans-resveratrol, selenium, vitamin E, vitaminC). Then, after 21 month treatment period, a selected heavy metal chelator was added at the dosage of 3 g/nocte forthe final 3 months study treatment. The parameters tested were: routine tests oxidized LDL-cholesterol, anti-oxidisedLDL, Cyclophilin-A (CyPA), plasminogen activator inhibitor-1 and CyPA gene expression. From this study it wouldappear that FPP, unlike the control antioxidant, significantly decreased oxidized-LDL and near normalizing the antiOx-LDL/Ox-LDL ratio (p<0.001) although unaffecting the lipid profile per sè. Moreover, only FPP decreasedcyclophilin-A plasma level and plasminogen activator-inhibitor (p<0.01) together with downregulating cyclophilin-Agene expression (p<0.01). Insulin resistance was only mildly improved. Heavy metals gut clearance proved to beeffectively enhanced by the chelator (p<0.01) and this was not affected by any of the nutraceuticals, nor it added anyfurther benefit to the biological action of FPP.

A 2-year Double-Blind RCT Follow-up Study with Fermented Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered Neurodegenerative Disease-Risk Factors

CATANZARO, Roberto
2017-01-01

Abstract

In recent years a number of studies have reported the significant relationship between metabolic syndrome andneurodegenerative disease. There is accumulating evidence that the interplay of combined genetic andenvironmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes maybe advocated for to explain the pandemic of neurodegenerative diseases. In recent years a specific FermentedPapaya Preparation (FPP) has been shown to significantly affect a number of redox signalling abnormalities in avariety of chronic diseases and as well in aging mechanisms either on experimental and on clinical ground. The aimof the present study was to evaluate FPP use in impending metabolic disease patients with potentiallyneurodegenerative disease clustered risk factors. The study population consisted of 90 patients aged 45-65 yearsold, with impending metabolic syndrome and previously selected as to be ApoE4 genotype negative. By applying aRCT, double-blind method, one group received FPP 4.5 g twice a day (the most common dosage utilized in priorclinical studies) while the other received an oral antioxidant cocktail (trans-resveratrol, selenium, vitamin E, vitaminC). Then, after 21 month treatment period, a selected heavy metal chelator was added at the dosage of 3 g/nocte forthe final 3 months study treatment. The parameters tested were: routine tests oxidized LDL-cholesterol, anti-oxidisedLDL, Cyclophilin-A (CyPA), plasminogen activator inhibitor-1 and CyPA gene expression. From this study it wouldappear that FPP, unlike the control antioxidant, significantly decreased oxidized-LDL and near normalizing the antiOx-LDL/Ox-LDL ratio (p<0.001) although unaffecting the lipid profile per sè. Moreover, only FPP decreasedcyclophilin-A plasma level and plasminogen activator-inhibitor (p<0.01) together with downregulating cyclophilin-Agene expression (p<0.01). Insulin resistance was only mildly improved. Heavy metals gut clearance proved to beeffectively enhanced by the chelator (p<0.01) and this was not affected by any of the nutraceuticals, nor it added anyfurther benefit to the biological action of FPP.
2017
Fermented papaya preparation; Redox balance; Antioxidant
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/30887
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